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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1988-8-3
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pubmed:abstractText |
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V beta segment (V beta 6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V beta 6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V beta 8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V beta 6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-2413106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-2578398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-3471350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-3489434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-4125922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6123534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6195289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6206178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6399977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6608055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2968436-6982474
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Lymphocyte Stimulatory...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2005-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2968436-Animals,
pubmed-meshheading:2968436-Animals, Newborn,
pubmed-meshheading:2968436-Antigens, Ly,
pubmed-meshheading:2968436-Antigens, Surface,
pubmed-meshheading:2968436-Immune Tolerance,
pubmed-meshheading:2968436-Lymph Nodes,
pubmed-meshheading:2968436-Mice,
pubmed-meshheading:2968436-Minor Lymphocyte Stimulatory Antigens,
pubmed-meshheading:2968436-Receptors, Antigen, T-Cell,
pubmed-meshheading:2968436-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:2968436-T-Lymphocytes,
pubmed-meshheading:2968436-Thymus Gland
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pubmed:year |
1988
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pubmed:articleTitle |
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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