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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-7-27
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pubmed:abstractText |
Human recombinant interferon-gamma (IFN-gamma) significantly increased the expression of receptors for IgE (Fc epsilon RII) on blood platelets. Fc epsilon RII was measured by specific binding of 125I-labeled IgE or flow cytometry experiments. Scatchard analysis of 125I-labeled IgE binding curves revealed that treatment with IFN-gamma increased the number of Fc epsilon RII but did not change the value of the association constant of Fc epsilon RII for 125I-labeled IgE. IFN-alpha had no effect on the expression or affinity of Fc epsilon RII. In addition to Fc epsilon RII, IFN-gamma also modified the expression of the glycoprotein IIb-IIIa complex on the platelet membrane.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-32
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2967768-Blood Platelets,
pubmed-meshheading:2967768-Flow Cytometry,
pubmed-meshheading:2967768-Gene Expression Regulation,
pubmed-meshheading:2967768-Humans,
pubmed-meshheading:2967768-Immunoglobulin E,
pubmed-meshheading:2967768-Interferon-gamma,
pubmed-meshheading:2967768-Platelet Membrane Glycoproteins,
pubmed-meshheading:2967768-Receptors, Fc,
pubmed-meshheading:2967768-Receptors, IgE,
pubmed-meshheading:2967768-Recombinant Proteins,
pubmed-meshheading:2967768-Stimulation, Chemical
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pubmed:year |
1988
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pubmed:articleTitle |
Recombinant human interferon-gamma induces increased IgE receptor expression on human platelets.
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pubmed:affiliation |
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
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pubmed:publicationType |
Journal Article
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