| pubmed-article:2967099 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C0234621 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:2967099 | lifeskim:mentions | umls-concept:C0004400 | lld:lifeskim |
| pubmed-article:2967099 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2967099 | pubmed:dateCreated | 1988-6-29 | lld:pubmed |
| pubmed-article:2967099 | pubmed:abstractText | The presence of insulin-like growth factor-II (IGF-II) in brain and cerebral spinal fluid prompted us to investigate the distribution of receptors for this peptide in rat brain slices. Human 125I-IGF-II (10 pM) was incubated for 16 h at 4 degrees C with thaw-mounted slices of rat brain from 11 different brain regions. Incubations in the absence or presence of excess unlabeled human IGF-II or insulin were performed and the labeled tissues were exposed to X-ray film for 4-7 days. Autoradiographs showed dense labeling in the granule layers of the olfactory bulbs, deep layers of the cerebral cortex, pineal gland, anterior pituitary, hippocampus (CA1-CA4, and dentate gyrus), and the granule cell layers of the cerebellum. Unlabeled IGF-II eliminated most of the binding in these brain regions while insulin produced only a minimal reduction in the amount of 125I-IGF-II bound. These results indicate that a neural receptor for IGF-II is uniquely distributed in rat brain tissue supporting the notion that this peptide might play an important role in neuronal functioning. | lld:pubmed |
| pubmed-article:2967099 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2967099 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2967099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2967099 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2967099 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2967099 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2967099 | pubmed:author | pubmed-author:ClemensJJ | lld:pubmed |
| pubmed-article:2967099 | pubmed:author | pubmed-author:SmithMM | lld:pubmed |
| pubmed-article:2967099 | pubmed:author | pubmed-author:KerchnerG AGA | lld:pubmed |
| pubmed-article:2967099 | pubmed:author | pubmed-author:MendelsohnL... | lld:pubmed |
| pubmed-article:2967099 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2967099 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2967099 | pubmed:volume | 445 | lld:pubmed |
| pubmed-article:2967099 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2967099 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2967099 | pubmed:pagination | 241-6 | lld:pubmed |
| pubmed-article:2967099 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:meshHeading | pubmed-meshheading:2967099-... | lld:pubmed |
| pubmed-article:2967099 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2967099 | pubmed:articleTitle | The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography. | lld:pubmed |
| pubmed-article:2967099 | pubmed:affiliation | Department of Biochemistry, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN 46285. | lld:pubmed |
| pubmed-article:2967099 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2967099 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2967099 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2967099 | lld:pubmed |
