Linked Life Data

2966248

Source:http://linkedlifedata.com/resource/pubmed/id/2966248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-6-2
pubmed:abstractText
To investigate the monocyte/macrophages function in patients with Crohn's disease (CD), phagocytosis, monocyte polykaryon formation and accessory cell function were studied. The number of yeast particles/monocyte in patients with CD was significantly higher (p less than 0.005) than that in healthy donors (HD). A significant increase (p less than 0.01) of fusion index was shown in CD patients in the absence of recombinant gamma-interferon (IFN gamma), while only a small amount of fusion was seen in HD. Accessory cell function of the monocytes from patients with CD was reduced, but 3H-thymidine incorporation was increased when the lymphocytes from patients with CD were cultured with the monocytes from HD. These results suggest that peripheral blood monocytes from patients with CD have abnormal functions, which may be involved in the pathogenesis of the granuloma and giant cell formation in CD patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0141-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-70
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Impaired monocyte macrophages function in patients with Crohn's disease.
pubmed:affiliation
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
pubmed:publicationType
Journal Article