Linked Life Data

2966182

Source:http://linkedlifedata.com/resource/pubmed/id/2966182

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-6-3
pubmed:abstractText
To determine whether atrial natriuretic factor (ANF) is detectable in human cerebrospinal fluid (CSF), I measured ANF in CSF samples obtained from subjects undergoing myelography for various neurological disorders. Immunoreactive ANF, measured by RIA, ranged from undetectable (less than 9.7) to 36 pmol/L. All measurable samples diluted in parallel in the RIA. Reverse phase high pressure liquid chromatography and subsequent RIA confirmed the presence of ANF, with most of the immunoreactivity eluting at the position of standard human ANF-(99-126). Simultaneous plasma ANF levels were measured in most individuals and the plasma concentrations were less than those in CSF; most of the immunoreactivity in plasma also eluted at the position of human ANF-(99-126). Thus, ANF is present in CSF in substantial amounts in some subjects with neurological disorders. Further, the CSF levels exceeded the circulating plasma ANF levels in most subjects. These results suggest that ANF in CSF is at least partially derived from production in the brain and/or is concentrated in the CSF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1080-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Atrial natriuretic factor is detectable in human cerebrospinal fluid.
pubmed:affiliation
Department of Medicine, Long Beach Veterans Hospital, California 90822.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't