| pubmed-article:2965642 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0175727 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0080141 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:2965642 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:2965642 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2965642 | pubmed:dateCreated | 1988-5-23 | lld:pubmed |
| pubmed-article:2965642 | pubmed:abstractText | The in vitro reactivity of purified murine Ly-2+ and L3T4+ T cells towards 2,4,6-trinitrophenyl (TNP)-modified syngeneic stimulator cells was analyzed. Both T cell subpopulations autonomously proliferated and produced interleukin 2. In either the Ly-2+ or L3T4+ T cell subset the frequencies of TNP-specific interleukin 2 (IL 2)-producing T lymphocyte precursors (IL 2 TL-p) were equally high (f = 1/400-1/1000). Clonally developing IL 2 TL of either T cell subset showed an exquisite antigen (TNP) specificity as shown by the split culture approach. TNP-specific Ly-2+ IL-2 TL used class I MHC (H-2Kk) gene products as major histocompatibility complex (MHC) restriction elements, while L3T4+ IL 2 TL proved to be class II MHC (H-2I-AkI-Ek) restricted. Clonal segregation analyses revealed that the majority of clonally developing TNP-reactive Ly-2+ TL segregated into either IL 2 TL-p or cytotoxic T lymphocyte presursors, i.e. both functions appear to be mutually exclusive. Less than 10% of the responding Ly-2+ T cells seemed to be bifunctional. These findings provide compelling evidence for the L3T4+ T cell-independent, autonomous reactivity of Ly-2+ T cells in MHC-restricted antigen-specific responses and suggest T-T cell interactions within the functional heterogenous Ly-2+ T cell population. | lld:pubmed |
| pubmed-article:2965642 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2965642 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2965642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2965642 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2965642 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2965642 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:2965642 | pubmed:author | pubmed-author:WagnerHH | lld:pubmed |
| pubmed-article:2965642 | pubmed:author | pubmed-author:SchmittJJ | lld:pubmed |
| pubmed-article:2965642 | pubmed:author | pubmed-author:KOCHF WFW | lld:pubmed |
| pubmed-article:2965642 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2965642 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:2965642 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2965642 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2965642 | pubmed:pagination | 325-32 | lld:pubmed |
| pubmed-article:2965642 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2965642 | pubmed:meshHeading | pubmed-meshheading:2965642-... | lld:pubmed |
| pubmed-article:2965642 | pubmed:meshHeading | pubmed-meshheading:2965642-... | lld:pubmed |
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| pubmed-article:2965642 | pubmed:meshHeading | pubmed-meshheading:2965642-... | lld:pubmed |
| pubmed-article:2965642 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2965642 | pubmed:articleTitle | Reactivity of Ly-2+ T cells against 2,4,6-trinitrophenyl (TNP)-modified syngeneic stimulator cells: specificity, frequency of interleukin 2-producing Ly-2+ helper T cells and clonal segregation from Ly-2+ cytotoxic T lymphocytes. | lld:pubmed |
| pubmed-article:2965642 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Ulm. | lld:pubmed |
| pubmed-article:2965642 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2965642 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2965642 | lld:pubmed |
