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rdf:type |
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lifeskim:mentions |
umls-concept:C0018213,
umls-concept:C0018894,
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0439859,
umls-concept:C0871261,
umls-concept:C1514485,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2362651,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
1988-3-23
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pubmed:abstractText |
We have studied cellular interactions among thyrocytes, intrathyroidal T cells and peripheral blood T cells from Graves' patients. In the autologous mixed lymphocyte reaction of Graves' patients, CD4+ cells were able to proliferate vigorously against autologous non-T cells, whereas CD8+ cells responded weakly to non-T cell stimulators. Furthermore, the proliferative response of the CD4+ 2H4+ suppressor-inducer T cell subset was increased like that of the CD4+ 2H4- helper T cell subset. In contrast to peripheral blood non-T cell stimulators, thyrocytes and intrathyroidal T cells had the ability to activate the CD4+ 2H4- helper T cell subset but were not able to cause proliferation both of CD4+ 2H4+ suppressor-inducer T cell and CD8+ suppressor/cytotoxic T cell subsets. The marked reduction in proliferative responses of CD4+ 2H4+ cells and CD8+ cells could not be attributed to a difference in kinetics or altered response to variable number of stimulator cells. On the basis of these findings, it is suggested that the concentration of the helper T cell subset may be progressively increased and suppressor circuits may be unable to be activated in thyroid tissues. These abnormalities in cellular interactions may induce the excessive production of autoantibodies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-2995430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3081570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3155461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3155770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3485022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3871967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3874876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-3930110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6133177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6134885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6138646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6197471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6205073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6223112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6238731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6327821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2962792-6389597
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
403-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2962792-Adolescent,
pubmed-meshheading:2962792-Adult,
pubmed-meshheading:2962792-Cell Division,
pubmed-meshheading:2962792-Female,
pubmed-meshheading:2962792-Graves Disease,
pubmed-meshheading:2962792-Humans,
pubmed-meshheading:2962792-Kinetics,
pubmed-meshheading:2962792-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:2962792-Male,
pubmed-meshheading:2962792-T-Lymphocytes,
pubmed-meshheading:2962792-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2962792-Thyroid Gland
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pubmed:year |
1987
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pubmed:articleTitle |
The remarkable proliferation of helper T cell subset in response to autologous thyrocytes and intrathyroidal T cells from patients with Graves' disease.
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pubmed:affiliation |
First Department of Internal Medicine, Nagasaki University School of Medicine.
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pubmed:publicationType |
Journal Article
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