| pubmed-article:2962740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2962740 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2962740 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2962740 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2962740 | pubmed:dateCreated | 1988-3-11 | lld:pubmed |
| pubmed-article:2962740 | pubmed:abstractText | The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearance of L3T4+ T cells, but also effectively abolished reactivity toward class II MHC antigens in vitro and in vivo. However, L3T4+ T-cell-depleted mice still reacted to class I MHC alloantigens in vivo: after immunization with class I MHC alloantigens Il-2 receptor-bearing T cells appeared in the draining lymph nodes, and developed antigen-specific cytolytic activity. Moreover, upon in vivo priming the frequencies of class I MHC-specific precursors of Il-2-producing and cytolytic Lyt2+ T lymphocytes increased up to 20-fold. L3T4+ T-cell-depleted mice rejected class I MHC-bearing skin grafts promptly. We conclude that not only in vitro but also in vivo Lyt2+ T cells remain reactive toward class I MHC antigens in the absence of L3T4+ T helper cells. | lld:pubmed |
| pubmed-article:2962740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2962740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2962740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2962740 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2962740 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:2962740 | pubmed:author | pubmed-author:WagnerHH | lld:pubmed |
| pubmed-article:2962740 | pubmed:author | pubmed-author:SteenHH | lld:pubmed |
| pubmed-article:2962740 | pubmed:author | pubmed-author:KOCHF WFW | lld:pubmed |
| pubmed-article:2962740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2962740 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:2962740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2962740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2962740 | pubmed:pagination | 148-57 | lld:pubmed |
| pubmed-article:2962740 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
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| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
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| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:meshHeading | pubmed-meshheading:2962740-... | lld:pubmed |
| pubmed-article:2962740 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2962740 | pubmed:articleTitle | L3T4+ T-cell-independent reactivity of Lyt2+ T cells in vivo. | lld:pubmed |
| pubmed-article:2962740 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Ulm, West Germany. | lld:pubmed |
| pubmed-article:2962740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2962740 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2962740 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2962740 | lld:pubmed |
