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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-3-11
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pubmed:abstractText |
The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearance of L3T4+ T cells, but also effectively abolished reactivity toward class II MHC antigens in vitro and in vivo. However, L3T4+ T-cell-depleted mice still reacted to class I MHC alloantigens in vivo: after immunization with class I MHC alloantigens Il-2 receptor-bearing T cells appeared in the draining lymph nodes, and developed antigen-specific cytolytic activity. Moreover, upon in vivo priming the frequencies of class I MHC-specific precursors of Il-2-producing and cytolytic Lyt2+ T lymphocytes increased up to 20-fold. L3T4+ T-cell-depleted mice rejected class I MHC-bearing skin grafts promptly. We conclude that not only in vitro but also in vivo Lyt2+ T cells remain reactive toward class I MHC antigens in the absence of L3T4+ T helper cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
148-57
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2962740-Animals,
pubmed-meshheading:2962740-Antibodies, Monoclonal,
pubmed-meshheading:2962740-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2962740-Antigens, Ly,
pubmed-meshheading:2962740-Cytotoxicity, Immunologic,
pubmed-meshheading:2962740-Graft Rejection,
pubmed-meshheading:2962740-H-2 Antigens,
pubmed-meshheading:2962740-Histocompatibility Antigens Class II,
pubmed-meshheading:2962740-Immunity, Cellular,
pubmed-meshheading:2962740-Interleukin-2,
pubmed-meshheading:2962740-Lymphocyte Cooperation,
pubmed-meshheading:2962740-Mice,
pubmed-meshheading:2962740-Skin,
pubmed-meshheading:2962740-Skin Transplantation,
pubmed-meshheading:2962740-T-Lymphocytes,
pubmed-meshheading:2962740-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2962740-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1988
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pubmed:articleTitle |
L3T4+ T-cell-independent reactivity of Lyt2+ T cells in vivo.
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pubmed:affiliation |
Department of Medical Microbiology and Immunology, University of Ulm, West Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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