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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-2-20
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pubmed:abstractText |
To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of alpha-human ANP-like immunoreactivity (alpha-hANP-LI) in human right auricles ranged from 13.8 to 593.5 micrograms/g, and the tissue alpha-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The alpha-hANP-LI in the human auricle consisted of 3 major components of ANP, gamma-human ANP (gamma-hANP), beta-human ANP (beta-hANP) and alpha-human ANP (alpha-hANP). The predominant component of alpha-hANP-LI was gamma-hANP in the mild CHF, whereas beta-hANP and/or alpha-hANP were prevailing in the severe CHF and, especially, beta-hANP was markedly increased in human failing hearts.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
60-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2962584-Adult,
pubmed-meshheading:2962584-Atrial Natriuretic Factor,
pubmed-meshheading:2962584-Chromatography, Gel,
pubmed-meshheading:2962584-Chromatography, High Pressure Liquid,
pubmed-meshheading:2962584-Female,
pubmed-meshheading:2962584-Heart Atria,
pubmed-meshheading:2962584-Heart Failure,
pubmed-meshheading:2962584-Humans,
pubmed-meshheading:2962584-Male,
pubmed-meshheading:2962584-Middle Aged,
pubmed-meshheading:2962584-Myocardium,
pubmed-meshheading:2962584-Radioimmunoassay
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pubmed:year |
1988
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pubmed:articleTitle |
Augmented synthesis of beta-human atrial natriuretic polypeptide in human failing hearts.
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pubmed:affiliation |
Department of Medicine, Kyoto University School of Medicine, Japan.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|