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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1988-1-26
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pubmed:abstractText |
Highly purified microvillar 110 kDa polypeptide-calmodulin (110K-cam) complex was confirmed to have ATPase activities characteristic of a myosin. The effect of F-actin on these activities was investigated. The Mg2+-ATPase is activated about 2-fold by F-actin in a dose-dependent fashion, whereas the K+-EDTA-ATPase is inhibited by greater than 90% by F-actin. These data provide evidence for a functional relationship between the ATPase activity of 110K-cam and its interaction with F-actin. They also extend the similarities between 110K-cam and myosin. The results suggest that higher cells contain in addition to myosin a second class of myosin-like molecules represented by 110K-cam.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
225
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-72
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2961614-Actins,
pubmed-meshheading:2961614-Adenosine Triphosphatases,
pubmed-meshheading:2961614-Animals,
pubmed-meshheading:2961614-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:2961614-Calcium-Transporting ATPases,
pubmed-meshheading:2961614-Calmodulin,
pubmed-meshheading:2961614-Enzyme Activation,
pubmed-meshheading:2961614-Intestines,
pubmed-meshheading:2961614-Magnesium,
pubmed-meshheading:2961614-Microvilli,
pubmed-meshheading:2961614-Myosins,
pubmed-meshheading:2961614-Potassium Chloride,
pubmed-meshheading:2961614-Rabbits
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pubmed:year |
1987
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pubmed:articleTitle |
ATPase activity of the microvillar 110 kDa polypeptide-calmodulin complex is activated in Mg2+ and inhibited in K+-EDTA by F-actin.
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pubmed:affiliation |
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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