Linked Life Data

2960556

Source:http://linkedlifedata.com/resource/pubmed/id/2960556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-12-24
pubmed:abstractText
The Ca2+-binding parvalbumin (PV) is possibly involved in the relaxation of fast-twitch muscle fibers and believed to be a marker for early muscular disturbances. The muscular content of parvalbumin has been shown to change with alterations of the relaxation speed that follow an experimentally changed nervous input. In hypo- and hyperthyroidism isometric twitch contraction and half-relaxation times are also altered, namely increased in hypothyroidism and decreased in hyperthyroidism. These changes are largely paralleled by modifications in the fiber type composition. Therefore we investigated the distribution and concentration of parvalbumin in extensor digitorum longus, soleus, and gastrocnemius muscles of rats by immunohistochemical and biochemical methods. The combined results of both procedures showed that parvalbumin distribution and concentration were largely unaffected in all thyroid states. This suggests that the expression of parvalbumin is neuronally controlled and not by thyroid hormones. Additionally our findings support the view that the changes in physiologic properties and fiber type composition are generated by a direct action of thyroid hormone on muscle fibers, and not via their nervous input.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
529-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Analysis of the Ca2+-binding parvalbumin in rat skeletal muscles of different thyroid states.
pubmed:affiliation
Institute of Anatomy, University of Zürich-Irchel, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't