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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1987-12-9
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pubmed:abstractText |
C1-Methylated derivatives of the potent 5-hydroxytryptamine (5-HT) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 1) were synthesized and tested for central 5-HT and dopamine receptor activity by use of a biochemical test method in rats. cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin (8) was found to be a 5-HT receptor agonist. The (+)-enantiomer of 8 had a potency equal to that of 1, whereas (-)-8 and the trans isomer (+/-)-9 were inactive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2105-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2959776-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:2959776-Animals,
pubmed-meshheading:2959776-Male,
pubmed-meshheading:2959776-Molecular Conformation,
pubmed-meshheading:2959776-Naphthalenes,
pubmed-meshheading:2959776-Rats,
pubmed-meshheading:2959776-Rats, Inbred Strains,
pubmed-meshheading:2959776-Receptors, Dopamine,
pubmed-meshheading:2959776-Receptors, Serotonin,
pubmed-meshheading:2959776-Serotonin,
pubmed-meshheading:2959776-Stereoisomerism,
pubmed-meshheading:2959776-Structure-Activity Relationship,
pubmed-meshheading:2959776-Tetrahydronaphthalenes
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pubmed:year |
1987
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pubmed:articleTitle |
(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist.
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pubmed:affiliation |
Department of Organic Pharmaceutical Chemistry, University of Uppsala,Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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