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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-11-12
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pubmed:abstractText |
The specificity of the type 2 insulinlike growth factor (IGF) receptor is evaluated in human placenta membranes and the human cell line K562. K562 cells have type 2 but not type 1 IGF receptors. Native IGF-2 isolated from human plasma and synthetic IGF-2 were equipotent in competing with labeled IGF-2 in both systems. Pure IGF-1 isolated from plasma, synthetic IGF-1 and recombinant IGF-1 could not crossreact with the type 2 IGF receptor in concentrations up to 1 microgram/ml in both systems. Studies on placenta membrane were done in the presence of 300 ug/ml insulin to block the type 1 IGF receptors. It is concluded that IGF-1, as well as insulin, cannot crossreact with the human type 2 IGF receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1206-12
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2959284-Binding, Competitive,
pubmed-meshheading:2959284-Cell Line,
pubmed-meshheading:2959284-Cell Membrane,
pubmed-meshheading:2959284-Humans,
pubmed-meshheading:2959284-Insulin-Like Growth Factor I,
pubmed-meshheading:2959284-Insulin-Like Growth Factor II,
pubmed-meshheading:2959284-Placenta,
pubmed-meshheading:2959284-Receptor, Insulin,
pubmed-meshheading:2959284-Receptors, Somatomedin,
pubmed-meshheading:2959284-Somatomedins
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pubmed:year |
1987
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pubmed:articleTitle |
The specificity of the human IGF-2 receptor.
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pubmed:affiliation |
Department of Endocrinology, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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