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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1987-11-4
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pubmed:databankReference |
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pubmed:abstractText |
Proteins that bind IgE play important roles in both the synthesis and function of IgE are therefore intimately involved in IgE-mediated human allergic disorders. This report describes the structure of an IgE-binding protein, as predicted from sequencing a cDNA cloned from rat basophilic leukemia cells. This protein contains two domains: the amino-terminal domain (140 amino acids) consists of a highly conserved repetitive amino acid sequence, Tyr-Pro-Gly-Pro/Gln-Ala/Thr-Pro/Ala-Pro-Gly-Ala, whereas the carboxyl-terminal domain (122 amino acids) shares significant sequence homology with a domain of lymphocyte/macrophage receptor for the Fc portion of IgG. Other proteins with this type of structure but with affinity for other immunoglobulin isotypes may exist and may represent a heretofore unidentified component of the immune system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-2877743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-2944118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-2946078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-2949326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-2983426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3011032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3017990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3024012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3087629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3858867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3873067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-3943125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-396780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-429343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-4812630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-56010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6083565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6085750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6174272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6190168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6206059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6209582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6231288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6329728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6417546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6431765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6452878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6457041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6457911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6863310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-6997135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-7108955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-7373045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-7410411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2958848-81546
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6859-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2958848-Amino Acid Sequence,
pubmed-meshheading:2958848-Animals,
pubmed-meshheading:2958848-Base Sequence,
pubmed-meshheading:2958848-Cell Line,
pubmed-meshheading:2958848-Immunoglobulin E,
pubmed-meshheading:2958848-Immunoglobulin G,
pubmed-meshheading:2958848-Molecular Sequence Data,
pubmed-meshheading:2958848-Receptors, Fc,
pubmed-meshheading:2958848-Receptors, IgE,
pubmed-meshheading:2958848-Receptors, IgG,
pubmed-meshheading:2958848-Repetitive Sequences, Nucleic Acid
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pubmed:year |
1987
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pubmed:articleTitle |
An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor.
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pubmed:affiliation |
Division of Molecular Biology, Medical Biology Institute, La Jolla, CA 92037.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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