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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1987-9-25
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pubmed:abstractText |
The aim of the first part of this study was to evaluate the effects of a new synthetic steroid (7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14), on anterior pituitary (AP) and neurointermediate pituitary lobe (NIL) contents and on circulating levels of beta-endorphin (beta-EP) in rats. Three weeks after ovariectomy, groups of 9 rats were treated with either Org OD 14 (2 or 10 micrograms/day/rat for 14 days) or a placebo. In addition, 2 groups of ovariectomized rats were also treated with oestradiol benzoate (EB) (2 or 10 micrograms/day/rat for 14 days) to compare the effectiveness of the new steroid with that of a classical oestrogenic substance. beta-Ep concentrations were measured in plasma and in AP and NIL extracts by means of double-antibody radioimmunoassay (RIA), employing a specific anti-camel beta-EP (C-terminal fragment). Both doses of Org OD 14 induced a significant dose-related increase in plasma and pituitary lobe beta-EP concentrations as compared with the results on placebo treatment. By comparison, EB was active only at a dose of 10 micrograms/day. Despite the common stimulatory effects of EB and Org OD 14 on pituitary beta-EP, these findings suggest that the two steroids have different modes of action. The second part of the study investigated the changes in beta-EP and beta-lipotrophin (beta-LPH) plasma levels in a group of post-menopausal women treated for 6 months with Org OD 14 (2.5 mg/day) in comparison with the levels in a placebo-treated group. The clinical efficacy of Org OD 14 treatment in post-menopausal symptoms was confirmed, as well as its lack of or only transient effect on plasma lipids and lipoproteins. beta-EP and beta-LPH plasma levels were significantly higher in the Org OD 14-treated group than in the placebo group as from the second month until the end of the observation period.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Norpregnenes,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Endorphin,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Lipotropin,
http://linkedlifedata.com/resource/pubmed/chemical/tibolone
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pubmed:status |
MEDLINE
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pubmed:issn |
0378-5122
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-48
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2957569-Adult,
pubmed-meshheading:2957569-Animals,
pubmed-meshheading:2957569-Castration,
pubmed-meshheading:2957569-Endorphins,
pubmed-meshheading:2957569-Female,
pubmed-meshheading:2957569-Humans,
pubmed-meshheading:2957569-Menopause,
pubmed-meshheading:2957569-Middle Aged,
pubmed-meshheading:2957569-Norpregnenes,
pubmed-meshheading:2957569-Pituitary Gland,
pubmed-meshheading:2957569-Rats,
pubmed-meshheading:2957569-Rats, Inbred Strains,
pubmed-meshheading:2957569-beta-Endorphin,
pubmed-meshheading:2957569-beta-Lipotropin
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pubmed:year |
1987
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pubmed:articleTitle |
Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and post-menopausal women.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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