Linked Life Data

2957529

Source:http://linkedlifedata.com/resource/pubmed/id/2957529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-9-25
pubmed:abstractText
Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-5031
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Renal effects of synthetic rat-atrial natriuretic peptide in nephron-reduced rats with nephrotoxic nephritis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't