Linked Life Data

2956388

Source:http://linkedlifedata.com/resource/pubmed/id/2956388

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-9-16
pubmed:abstractText
To evaluate the role of the autonomic nervous system in the regulation of atrial natriuretic peptide (ANP) secretion, the secretory responses of isolated perfused rat hearts to adrenaline and acetylcholine were studied. Infusion of adrenaline produced a dose-dependent rise in heart rate and contractile force associated with a marked increase in perfusate ANP immunoreactivity. The ANP response was almost completely abolished by the alpha-adrenoceptor antagonist phentolamine (10(-6)) and attenuated by the beta-adrenoceptor antagonist metoprolol (10(-5)). Thus, both alpha- and beta-adrenoceptors may mediate the adrenaline effect on ANP release. Perfusion of the isolated heart with 10(-6) or 10(-5) acetylcholine resulted in a short rise in hormone release followed by a gradual decline. The negative ionotropic and chronotropic effects of acetylcholine and the rise in ANP induced by acetylcholine were blocked by atropine, suggesting that a muscarinic receptor is involved. The finding that both adrenaline and acetylcholine alter ANP secretion rate points to the participation of autonomic nerves in the regulation of ANP release from atrial cardiocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S538-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Regulation of atrial natriuretic peptide secretion.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't