Linked Life Data

2956186

Source:http://linkedlifedata.com/resource/pubmed/id/2956186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-8-28
pubmed:abstractText
Using different experimental approaches we here show that the suppression and cytotoxicity generated during a one-way mixed lymphocyte culture (MLC) are mediated by a single cell population, in this case the cytotoxic T lymphocyte (CTL). Results of limiting-dilution analysis of cells from a 4-day MLC demonstrate the coexpression of both functions and argue against the existence of a separate suppressor cell population that regulates the in vitro alloresponse. The suppressive quality of CTL is also exemplified in cells with a clonal origin, such as cloned cytotoxic T lymphocytes and the mouse X rat hybridoma PC60. Further experiments demonstrate that this suppression is not primarily mediated through lysis of the stimulator cells, and studies in the PC60 model suggest that lysis and suppression may have different induction requirements.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Alloinduced suppression and cytotoxicity: two functions of a single cell.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't