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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1987-6-9
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pubmed:abstractText |
The suppression of contact hypersensitivity (CHS) after a single exposure to ultraviolet (UV) radiation provides an excellent model system with which to study both the activation and the mode of action of suppressor T cells. Suppression of CHS after UV radiation is mediated by hapten-specific suppressor T cells (UVTs). These cells have a broad range of activity: CHS and antibody production in vivo and the generation of cytolytic T lymphocytes (CTL) and T-cell proliferative responses in vitro are suppressed by UVTs. The present study is concerned with determining the target of UVTs. The UVTs could suppress the response to hapten-modified T-dependent antigens, such as trinitrophenyl (TNP)-modified sheep erythrocytes (TNP-SRBC) or TNP-conjugated bovine serum albumin (TNP-BSA), but had no suppressive effect on the response to a T-independent antigen, TNP-conjugated lipopolysaccharide (TNP-LPS). The UVTs also suppressed the generation of interleukin-2 (IL-2) in vitro. The suppression of CTL generation in vitro and CHS in vivo could be overcome by the addition of exogenous IL-2. These data suggest that UVTs suppress the immune response by affecting T-helper cell function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-13957684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-160568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-2578432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-2579166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-2940172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-300876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-301091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-302510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-308990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-3155765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-3160804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-3855702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-3928175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-4139281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-4547153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6034749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6210958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6223958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6228590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6234069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6237155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6237976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6237978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6445861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6605225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6609192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-6979573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-7251064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2952584-92524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2952584-Animals,
pubmed-meshheading:2952584-Antibody Formation,
pubmed-meshheading:2952584-Antigens, T-Independent,
pubmed-meshheading:2952584-Dermatitis, Contact,
pubmed-meshheading:2952584-Female,
pubmed-meshheading:2952584-Immune Tolerance,
pubmed-meshheading:2952584-Interleukin-2,
pubmed-meshheading:2952584-Mice,
pubmed-meshheading:2952584-Mice, Inbred BALB C,
pubmed-meshheading:2952584-Mice, Inbred C3H,
pubmed-meshheading:2952584-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2952584-T-Lymphocytes, Regulatory,
pubmed-meshheading:2952584-Ultraviolet Rays
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pubmed:year |
1987
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pubmed:articleTitle |
The effect of ultraviolet radiation-induced suppressor cells on T-cell activity.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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