| pubmed-article:2951120 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:2951120 | lifeskim:mentions | umls-concept:C2709063 | lld:lifeskim |
| pubmed-article:2951120 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2951120 | pubmed:dateCreated | 1987-5-6 | lld:pubmed |
| pubmed-article:2951120 | pubmed:abstractText | Insulin binding, glucose transport, and glucose metabolism were investigated in isolated adipocytes from 11 lean and 13 obese patients with non-insulin-dependent diabetes mellitus. Insulin binding at 15 degrees C was reduced by 35% (p less than 0.01) in both lean and obese diabetic patients, whereas insulin binding (or uptake) at 37 degrees C was similar in diabetic patients and healthy controls. In lean diabetic patients both non-insulin-mediated (basal) and maximally insulin-stimulated glucose transport and metabolism were significantly reduced (all p less than 0.01). The percentage responses to insulin were also markedly reduced (p less than 0.05, p less than 0.02). In obese diabetic patients basal glucose transport was reduced (p less than 0.01) but basal glucose metabolism was not. Insulin-stimulated glucose transport and metabolism were significantly reduced (p less than 0.01, p less than 0.05). The percentage responses were reduced compared to healthy controls (p less than 0.05, p less than 0.05) but higher than in lean diabetic patients (p less than 0.05). We conclude that adipocytes isolated from both lean and obese patients with non-insulin-dependent diabetes mellitus are characterized by severely depressed non-insulin-mediated and insulin-mediated glucose transport and depressed insulin-mediated glucose metabolism. The major defect seems to be a reduced maximal effect of insulin on glucose metabolism, suggesting post-binding and post-transport abnormalities. | lld:pubmed |
| pubmed-article:2951120 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2951120 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2951120 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2951120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2951120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2951120 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2951120 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2951120 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2951120 | pubmed:issn | 0742-3071 | lld:pubmed |
| pubmed-article:2951120 | pubmed:author | pubmed-author:HjøllundEE | lld:pubmed |
| pubmed-article:2951120 | pubmed:author | pubmed-author:PedersenOO | lld:pubmed |
| pubmed-article:2951120 | pubmed:author | pubmed-author:Beck-NielsenH... | lld:pubmed |
| pubmed-article:2951120 | pubmed:author | pubmed-author:SørensenN SNS | lld:pubmed |
| pubmed-article:2951120 | pubmed:author | pubmed-author:RichelsenBB | lld:pubmed |
| pubmed-article:2951120 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2951120 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2951120 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2951120 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2951120 | pubmed:pagination | 468-73 | lld:pubmed |
| pubmed-article:2951120 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:meshHeading | pubmed-meshheading:2951120-... | lld:pubmed |
| pubmed-article:2951120 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2951120 | pubmed:articleTitle | Defective non-insulin-mediated and insulin-mediated glucose transport and metabolism in adipocytes from obese and lean patients with untreated type 2 diabetes mellitus. | lld:pubmed |
| pubmed-article:2951120 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2951120 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2951120 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2951120 | lld:pubmed |
