Linked Life Data

2950968

Source:http://linkedlifedata.com/resource/pubmed/id/2950968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-5-20
pubmed:abstractText
The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied. A single ECS induced a transient decrease in the hypothalamic ir-dynorphin, but did not influence the peptide content in the spinal cord, hippocampus and neurointermediate lobe of the pituitary. In contrast, the single ECS only slightly decreased the ir-beta-endorphin level in the hypothalamus, but caused a considerable fall in the peptide content in both lobes of the pituitary. A repeated ECS (every day for 9 days and 3 times a week for 3 weeks) markedly increased the ir-dynorphin content in the hypothalamus by 28 and 56%, respectively. Irrespective of the paradigm used, the repeated ECS strongly influenced spinal dynorphin neurons. At the beginning of our experiment (ECS applied 3 times) a fall in the peptide levels could be observed, but a longer treatment (ECS applied 9 times) led to its enhancement. The repeated ECS also induced a gradual decrease in the hippocampal ir-dynorphin level, followed by a long-term, rebound increase. In contrast to those numerous changes evoked in the dynorphin system, the repeated ECS did not evoke any changes in the hypothalamic and pituitary ir-beta-endorphin levels. As shown in the behavioral experiment, an acute ECS treatment resulted in a moderate increase in the pain threshold, measured by tail-flick and hot-plate tests. A prolonged ECS administration (3, 6 and 9 times) markedly enhanced the ECS-induced analgesia and catalepsy.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
403
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Single and repeated electroconvulsive shock differentially affects the prodynorphin and pro-opiomelanocortin system in the rat.
pubmed:publicationType
Journal Article