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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1987-4-6
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pubmed:abstractText |
We describe an unusual type of cytopathology in which uninfected CD4+ (helper/inducer) cells (cells expressing the human leukocyte antigen CD4) interact with cells persistently infected with the human immunodeficiency virus (HIV). Prior antigenic stimulation was not required, since CD4+ cells taken either from healthy persons without anti-HIV antibodies or from individuals with anti-HIV antibodies were capable of inducing cytolysis. Neither CD8+ (suppressor/cytotoxic) nor CD16+ (natural killer) cells mediated the reaction. Light microscopic and autoradiographic studies revealed that, prior to cytolysis, multinucleated giant cells were formed from fusions between HIV-infected cells and large numbers of uninfected CD4+ lymphocytes. These data may explain the paradox that exists in vivo in which a dramatic depletion of CD4+ lymphocytes occurs in the presence of a small number of HIV-infected CD4+ cells. These new insights into the pathogenesis of acquired immunodeficiency syndrome (AIDS) may lead to future therapeutic strategies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-150448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2410140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2416802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2418502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2981428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2981429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2983221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-2995487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-299761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3001934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3003749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3010463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3014648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3016552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-3962603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-423767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6083454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6092954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6181900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6189183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6195252,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6203980,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6542214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6603314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6607776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6796496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6968783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6972304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2950525-6981813
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1429-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1987
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pubmed:articleTitle |
Fusion as a mediator of cytolysis in mixtures of uninfected CD4+ lymphocytes and cells infected by human immunodeficiency virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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