Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-3-9
pubmed:abstractText
Clonal expansion of T lymphocytes of the helper/inducer class is generally thought to be mediated by an interleukin 2 (IL-2)-dependent autocrine mechanism. Thus, T cells stimulated by antigens or mitogenic lectins secrete IL-2 and, under appropriate conditions, express membrane receptors for IL-2, and the specific hormone-receptor interaction induces cellular proliferation. Recent studies indicate that B-cell stimulatory factor 1 (BSF-1) is secreted by T cells and is capable of stimulating T-cell proliferation. We now report that BSF-1 and not IL-2 is the sole autocrine growth factor for certain cloned lines of inducer T lymphocytes. On stimulation by the lectin concanavalin A, anti-receptor antibody, or specific antigen with antigen-presenting cells, such clones secrete a lymphokine that stimulates DNA synthesis by the "IL-2 indicator line," HT2, but is identified as BSF-1 by specific inhibition with monoclonal antibodies. The proliferative response of such BSF-1-secreting clones to receptor-mediated signals is dependent on BSF-1 and not IL-2. These results demonstrate a function of BSF-1 and confirm the existence of a previously unknown autocrine pathway of T-cell activation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-2410498, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-2419430, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-2582266, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-2933048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-2983318, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3005865, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3083412, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3090545, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3486902, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3486939, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3875657, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3877141, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3919312, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-3932582, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6193236, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6207262, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6235287, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6432904, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6443342, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-6977612, http://linkedlifedata.com/resource/pubmed/commentcorrection/2949327-92524
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
824-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.