Linked Life Data

2948294

Source:http://linkedlifedata.com/resource/pubmed/id/2948294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-2-3
pubmed:abstractText
We compared the abilities of four TXA2/PGH2 receptor antagonists, AH 23,848, SQ 29,548, BM 13.177 and BM 13.505, to inhibit aggregation of human and canine platelet rich plasma (PRP) induced by the stable cyclic endoperoxide analog, U46619, alone (human) or in combination with epinephrine (dog). The rank orders of potency of these antagonists, which correlated well between human (h) and canine (c) preparations were [IC50]: SQ 29,548 [28 nM (h) and 92 nM (c)] greater than AH 23,848 [0.5 microM (h) and 0.6 microM (c)] congruent to BM 13.505 [0.4 microM (h) and 0.8 microM (c)] greater than BM 13.177 [3.9 microM (h) and 4.4 microM (c)]. The second wave of aggregation of human PRP induced by epinephrine and platelet activating factor (PAF) was abolished by similar concentrations of the TXA2/PGH2 antagonists, whereas aggregation of canine PRP induced by ADP, serotonin plus epinephrine, or PAF was unaffected by these concentrations of the TXA2/PGH2 antagonists. Epinephrine plus U46619-stimulated aggregation of canine PRP was abolished by RX 781094 (1 microM) but not by prazosin (10(-4) M), selective alpha 2- and alpha 1-adrenoceptor antagonists, respectively. Thus, four selective TXA2/PGH2 receptor antagonists, compared in two species, yield IC50's ranging from 28 nM to 4 microM and nearly identical rank orders of potency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0049-3848
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists.
pubmed:publicationType
Journal Article, In Vitro