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rdf:type |
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lifeskim:mentions |
umls-concept:C0003313,
umls-concept:C0005789,
umls-concept:C0005821,
umls-concept:C0021644,
umls-concept:C0030705,
umls-concept:C0035309,
umls-concept:C0332307,
umls-concept:C0334094,
umls-concept:C0439849,
umls-concept:C1704241,
umls-concept:C1749467
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pubmed:issue |
1
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pubmed:dateCreated |
1987-1-27
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pubmed:abstractText |
The possible correlation between soluble immune factors and platelet and coagulation factors has been evaluated in Type 1 diabetic patients with and without proliferative retinopathy, and in non-diabetic controls. Soluble immune complexes, platelet factor IV (PF4), beta-thromboglobulin, fibrinogen, factor VIII related antigen and anti-thrombin III were significantly increased in Type 1 diabetic patients with retinopathy as compared to non-diabetic controls. Fibrinogen and anti-thrombin III were also higher in those patients with retinopathy compared to those without retinopathy. A significant correlation was found between positive values of soluble immune complexes and increased levels of PF4 and beta-thromboglobulin in diabetic patients with retinopathy. The presence of soluble immune complexes and insulin-anti-insulin complexes was associated with a significantly greater number of elevated haemostatic factors in retinopathic patients. Our findings suggest that the interaction of platelets and soluble immune complexes or insulin-anti-insulin complexes may be pathologically relevant to the development of diabetic retinopathy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-1251342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-1251352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-13726460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-14087614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-332422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-4110999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-509177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-57793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-5959431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-606435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6159242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6160890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-63211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6383924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6603299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6611302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6759215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6971334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6983988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6994929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-6998615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-7008587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-7036632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-7297792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-73486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-7372028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-74664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-756468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2947762-989665
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2947762-Adult,
pubmed-meshheading:2947762-Antigen-Antibody Complex,
pubmed-meshheading:2947762-Antithrombin III,
pubmed-meshheading:2947762-Blood Coagulation Factors,
pubmed-meshheading:2947762-Blood Platelets,
pubmed-meshheading:2947762-Diabetes Mellitus, Type 1,
pubmed-meshheading:2947762-Diabetic Retinopathy,
pubmed-meshheading:2947762-Female,
pubmed-meshheading:2947762-Fibrinogen,
pubmed-meshheading:2947762-Humans,
pubmed-meshheading:2947762-Immunoglobulin G,
pubmed-meshheading:2947762-Insulin Antibodies,
pubmed-meshheading:2947762-Male,
pubmed-meshheading:2947762-Platelet Factor 4,
pubmed-meshheading:2947762-beta-Thromboglobulin
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pubmed:year |
1986
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pubmed:articleTitle |
The relationship of soluble immune complexes, insulin antibodies and insulin-anti-insulin complexes to platelet and coagulation factors in type 1 diabetic patients with and without proliferative retinopathy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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