Linked Life Data

2946837

Source:http://linkedlifedata.com/resource/pubmed/id/2946837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-1-2
pubmed:abstractText
T helper lymphocytes only recognize the antigen to which they are directed if it is 'presented' to them by a cell expressing the same class II major histocompatibility complex (MHC) antigen as themselves. Since the target cells of most organ specific autoimmune diseases do not normally express class II MHC proteins on their surface, any cell specific surface antigens they possess may never have been presented, and therefore immunological tolerance to them may not exist. The target cells in several organ specific autoimmune diseases have been shown to express class II MHC aberrantly and this expression may have allowed presentation of such cell specific surface antigens to potentially autoreactive T helper lymphocytes. It has therefore been proposed that aberrant expression of class II MHC antigens may be an initiating factor in certain autoimmune diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3417
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-11
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Class II major histocompatibility complex and organ specific autoimmunity in man.
pubmed:publicationType
Journal Article, Review