Linked Life Data

2946826

Source:http://linkedlifedata.com/resource/pubmed/id/2946826

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-12-23
pubmed:abstractText
In the present investigation we sought to determine whether spinal vasopressin or oxytocin of hypothalamic origin contributes to cardiovascular regulatory mechanisms. Exogenous vasopressin or oxytocin was injected into the spinal subarachnoid space of conscious, freely moving rats. Oxytocin had no effect on heart rate or blood pressure. However, vasopressin produced a marked increase in arterial pressure and a modest bradycardia. Previous intrathecal injection of a specific V1 vasopressin receptor antagonist completely prevented the haemodynamic effects expected after subsequent intrathecal injection of vasopressin. On the other hand, the increase in blood pressure and heart rate produced by stimulation of the paraventricular nucleus (PVN) was not prevented by the intrathecal antagonist. These data suggest that vasopressin can act specifically on spinal receptors to influence cardiovascular parameters. However, these spinal receptors do not appear to be functionally involved in the haemodynamic response produced by stimulation of the PVN.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S181-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The paraventricular nucleus and cardiovascular regulation: role of spinal vasopressinergic mechanisms.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't