|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1987-1-9
|
|
pubmed:abstractText |
The effect of purified human plasma fibronectin on stimulation of human platelets with crosslinked immunoglobulin G (IgG) was tested by means of aggregometry, 14C-serotonin release and fibronectin-to-platelet binding experiments. Incremental additions of fibronectin to gel-filtered platelets (8 X 10(8)/ml) followed by 25 micrograms/ml bisdiazoniumbenzidine (BDB)-crosslinked IgG produced a dose-related inhibition of platelet aggregation and suppression of 14C-serotonin release from the platelets. Evidence was obtained that upon stimulation of the platelets with BDB-IgG, fibronectin becomes bound to its receptor and that further platelet activation is inhibited when a sufficient number of receptors is occupied.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0007-1048
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
64
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
299-307
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2946316-Benzidines,
pubmed-meshheading:2946316-Dose-Response Relationship, Drug,
pubmed-meshheading:2946316-Fibronectins,
pubmed-meshheading:2946316-Humans,
pubmed-meshheading:2946316-Immunoglobulin G,
pubmed-meshheading:2946316-Platelet Aggregation,
pubmed-meshheading:2946316-Receptors, Fibronectin,
pubmed-meshheading:2946316-Receptors, Immunologic,
pubmed-meshheading:2946316-Serotonin,
pubmed-meshheading:2946316-Time Factors
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
Fibronectin-mediated inhibition of human platelet activation by crosslinked immunoglobulin G.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
