Linked Life Data

2946284

Source:http://linkedlifedata.com/resource/pubmed/id/2946284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-12-15
pubmed:abstractText
Surface membrane studies of cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) showed that they had an OKT3+, OKT4-, OKT8+ phenotype which is consistent with the phenotype of normal circulating peripheral blood suppressor/cytotoxic T-lymphocytes. The cells were HLA-DR+, anti-Tac-, SmIg- and E rosette+. Parallel studies in vitro showed that the T-CLL cells had a marked suppressive effect on both the mixed lymphocyte culture (MLC) proliferative response and the activation of cytotoxic T-lymphocytes. The T-CLL cells failed to respond or stimulate in MLC and were not directly cytotoxic to allogeneic peripheral blood lymphocyte targets. Both the suppression of the MLC and the cytotoxic responses depended on the presence of the T-CLL cells and not T-CLL culture supernatants. The T-CLL cells did not suppress the production of polyclonal antibody and did not produce interleukin-2 to levels above normal control lymphocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0004-8291
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
In vitro function of a T-cell chronic lymphocytic leukemia with suppressor cell phenotype.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't