Linked Life Data

2945054

Source:http://linkedlifedata.com/resource/pubmed/id/2945054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1986-11-12
pubmed:abstractText
The differentiation-inducer activity of the aromatic retinoid etretin and of its ethyl ester etretinate (Tigazon) was tested on the human myelomonocytic leukemia cell lines HL-60 and U-937 and compared to that of retinoic acid. Whereas all-trans and 13-cis isomers of retinoic acid were equally potent in inducing the differentiation of about 80% of the cells of both lines, etretin and etretinate were found to be totally ineffective. These results indicate that neither compounds should be used in vivo in the treatment of acute myelocytic leukemia patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-2126
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1079-81
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Inefficacy of the synthetic aromatic retinoid etretinate and of its free acid on the in-vitro differentiation of leukemic cells.
pubmed:publicationType
Journal Article