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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1986-11-7
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pubmed:abstractText |
The pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery (100 mg, n = 8; 200 mg n = 18) have been studied. Following 100 mg therapeutic serum levels were maintained for approximately 40 min only and tissue concentrations were frequently less than 0.15 mg/kg. 200 mg maintained therapeutic serum levels for at least 150 min and produced mean concentrations in fat, muscle, peritoneum and gut wall of 1.04, 1.94, 1.59, and 3.39 mg/kg respectively. 200 mg iv ciprofloxacin would appear to provide adequate serum and tissue concentrations for at least 150 min.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
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pubmed:issn |
0305-7453
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2944864-Abdominal Muscles,
pubmed-meshheading:2944864-Aged,
pubmed-meshheading:2944864-Bile,
pubmed-meshheading:2944864-Ciprofloxacin,
pubmed-meshheading:2944864-Digestive System,
pubmed-meshheading:2944864-Digestive System Surgical Procedures,
pubmed-meshheading:2944864-Female,
pubmed-meshheading:2944864-Humans,
pubmed-meshheading:2944864-Kinetics,
pubmed-meshheading:2944864-Male,
pubmed-meshheading:2944864-Middle Aged,
pubmed-meshheading:2944864-Peritoneum,
pubmed-meshheading:2944864-Tissue Distribution
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pubmed:year |
1986
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pubmed:articleTitle |
Pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|