Linked Life Data

2943943

Source:http://linkedlifedata.com/resource/pubmed/id/2943943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-10-2
pubmed:abstractText
A theoretical model based on molecular mechanisms of both dynein cross-bridges and radial spokes is used to study bend propagation by eukaryotic flagella. Though nine outer doublets are arranged within an axoneme, a simplified model with four doublets is constructed on the assumption that cross-bridges between two of the four doublets are opposed to those between the other two, corresponding to the geometric array of cross-bridges on the 6-9 and the 1-4 doublets in the axoneme. We also assume that external viscosity is zero, whereas internal viscosity is non-zero in order to reduce numerical complexity. For demonstrating flagellar movement, computer simulations are available by dividing a long flagellum into many straight segments. Considering the fact that dynein cross-bridge spacing is almost equal to attachment site spacing, we may use a localized cross-bridge distribution along attachment sites in each straight segment. Dynamics of cross-bridges are determined by a three-state model, and effects of radial spokes are represented by a periodic mechanical potential whose periodicity is considered to be a stroke distance of the radial spoke. First of all, we examine the model of a short segment to know basic properties of the system. Changing parameters relating to "activation" of cross-bridges, our model demonstrates various phenomena; for example "excitable properties with threshold phenomena" and "limit cycle oscillation". Here, "activation" and "inactivation" (i.e. switching mechanisms) between a pair of oppositely-directed cross-bridges are essential for generation of excitable or oscillatory properties. Next, the model for a flagellar segment is incorporated into a flagellum with a whole length to show bending movement. When excitable properties of cross-bridges, not oscillatory properties, are provided along the length of the flagellum and elastic links between filaments are presented at the base, then our model can demonstrate self-organization of bending waves as well as wave propagation without special feedback control by the curvature of the flagellum. Here, "cooperative interaction" between adjacent short segments, based on "cooperative dynamics" of cross-bridges, is important for wave propagation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-5193
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-33
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
A model of flagellar movement based on cooperative dynamics of dynein-tubulin cross-bridges.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't