Linked Life Data

2942753

Source:http://linkedlifedata.com/resource/pubmed/id/2942753

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-9-18
pubmed:abstractText
In 41 patients with primary Raynaud's phenomenon (PRP) the effectiveness of the serotonin receptor blocker Ketanserin has been studied in a double-blind cross-over investigation and during an additional long-term open study. Objective assessments of the severity of PRP in the patients were obtained by measuring Digital Skin Temperature (DST), Digital systolic Blood Pressure (DBP) and Doppler Spectral Analysis (DOSA) of the radial and ulnar artery. All measurements were performed both before and after cold provocation. Thirty one (78%) of the patients clinically improved on Ketanserin, while only 1 patient (2.3%) improved on placebo. DST significantly increases on Ketanserin treatment. On Ketanserin treatment DBP measurements show a significant increase in the digit to brachial systolic blood pressure index (DBI) after cold provocation. DOSA showed a significant decrease of the downslope of the spectra of both radial and ulnar artery on treatment. This downslope is indicative for peripheral resistance. Neither blood chemistry nor systemic blood pressure showed any change during Ketanserin treatment. The results of the study suggest that orally administered Ketanserin can be an effective and well tolerated treatment for minimizing subjective complaints in PRP patients. Ketanserin results in an increased DST and DBP combined with a decreased peripheral resistance as measured on the radial and ulnar artery. After treatment, Ketanserin does not show any side effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0740-9451
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
657-85
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Quantitative study of the effects of Ketanserin in patients with primary Raynaud's phenomenon. A randomized, double blind, placebo controlled investigation and an additional long term open trial.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial