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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1980-3-24
|
| pubmed:abstractText |
Experiments were performed to test the hypothesis that 5-Fluorouracil (5-FU) would delay or prevent healing of large-bowel anastomoses. The caecums of 120 specific-pathogen-free rats were transected and reanastomosed at once. Daily intravenous injections of 5-FU were given to half the rats, the other half being controls and receiving an equal volume of saline. At Days 5, 7 and 10, standard-sized sections of sutire line were pulled apart, and the force required to do this was recorded. At five days the strengths of the anastomoses in the 5-FU treated animals were only 25% of that of the controls, but by ten days they were over 60% of the strength of the controls. It was concluded that 5-FU delayed, but did not prevent, healing, and that it would be safe to use it in the early postoperative period, but not until several days after operation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0004-8682
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
743-5
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1979
|
| pubmed:articleTitle |
Retardation of healing of large-bowel anastomoses by 5-fluorouracil.
|
| pubmed:publicationType |
Journal Article
|