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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-8-6
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pubmed:abstractText |
To define molecular signals elaborated by inducer populations supporting growth or differentiation of T8+ cells, we collected supernatants of pokeweed mitogen (PWM)-stimulated cultures depleted of T8+ cells. When added to purified T8+ cells, these supernatants caused significant proliferation. PWM plus interleukin 2 (IL-2) in amounts equivalent to those in the supernatant could not reconstitute the response caused by the supernatant. T8+ cells activated by supernatants obtained from PWM-pulsed T4+ cells suppressed fresh PWM cultures. Although exhibiting little proliferation, T8+ cells cultured for 6 d in PWM plus IL-2 still suppressed a fresh PWM response. The supernatants therefore contain an additional T suppressor cell growth factor (TsGF). Elaboration of TsGF required radiosensitive T4+Leu8+ cells. Molecular weight determination by high performance liquid chromatography gave a single peak of TsGF activity at approximately 8,000. Finally, whereas TsGF in the absence of IL-2 could not support the proliferation of T suppressor cells, it did cause T8+ cells to become strongly IL-2 receptor-positive.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-2987968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-3871453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-3878925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-448083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-5726146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6196379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6205073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6221885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6228578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6229576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6235287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6237264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6255556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6352804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6429034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-65285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6604277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6606011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6611371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6804369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6966400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-6968783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-7000676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-7042544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2941453-92524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Pokeweed Mitogens
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
214-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2941453-Antibodies, Monoclonal,
pubmed-meshheading:2941453-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2941453-Antigens, Surface,
pubmed-meshheading:2941453-Cell Division,
pubmed-meshheading:2941453-Growth Substances,
pubmed-meshheading:2941453-HLA-DR Antigens,
pubmed-meshheading:2941453-Histocompatibility Antigens Class II,
pubmed-meshheading:2941453-Humans,
pubmed-meshheading:2941453-Interferon-gamma,
pubmed-meshheading:2941453-Interleukin-1,
pubmed-meshheading:2941453-Interleukin-2,
pubmed-meshheading:2941453-Molecular Weight,
pubmed-meshheading:2941453-Pokeweed Mitogens,
pubmed-meshheading:2941453-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:2941453-T-Lymphocytes, Regulatory
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pubmed:year |
1986
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pubmed:articleTitle |
Proliferative signals for suppressor T cells. Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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