Linked Life Data

2941372

Source:http://linkedlifedata.com/resource/pubmed/id/2941372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1986-7-25
pubmed:abstractText
Two doses of synthetic atrial natriuretic peptide (0.5 and 5.0 micrograms/min) and its vehicle were infused intravenously for 4 hours in eight salt-loaded normal volunteers, and the effect on blood pressure, heart rate, renal hemodynamics, solute excretion, and secretion of vasoactive hormones was studied. The 0.5 micrograms/min infusion did not alter blood pressure or heart rate, whereas the 5.0 micrograms/min infusion significantly reduced the mean pressure by 20/9 mm Hg after 2.5 to 3 hours and increased the heart rate slightly. Inulin clearance was not significantly changed, but the mean p-aminohippurate clearance fell by 13 and 32% with the lower and higher doses, respectively. Urinary excretion of sodium and chloride increased slightly with the lower dose. With the higher dose, a marked increase in urinary excretion of sodium, chloride, and calcium was observed, reaching a peak during the second hour of the infusion. Potassium and phosphate excretion did not change significantly. A brisk increase in urine flow rate and fractional water excretion was seen only during the first hour of the high-dose infusion. Signs and symptoms of hypotension were observed in two subjects. No change in plasma renin activity, angiotensin II, or aldosterone was observed during either infusion, but a marked increase occurred after discontinuation of the high-dose infusion. In conclusion, the 5 micrograms/min infusion induced a transient diuretic effect, delayed maximal natriuretic activity, and a late fall in blood pressure, with no change in inulin clearance but a dose-related decrease in p-aminohippurate clearance. Despite large amounts of sodium excreted and blood pressure reduction, no counterregulatory changes were observed in the renin-angiotensin-aldosterone system or plasma vasopressin levels during the infusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0194-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
II96-105
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2941372-Adult, pubmed-meshheading:2941372-Aldosterone, pubmed-meshheading:2941372-Angiotensin II, pubmed-meshheading:2941372-Atrial Natriuretic Factor, pubmed-meshheading:2941372-Blood Pressure, pubmed-meshheading:2941372-Body Water, pubmed-meshheading:2941372-Calcium, pubmed-meshheading:2941372-Chlorides, pubmed-meshheading:2941372-Glomerular Filtration Rate, pubmed-meshheading:2941372-Heart Rate, pubmed-meshheading:2941372-Humans, pubmed-meshheading:2941372-Kidney, pubmed-meshheading:2941372-Male, pubmed-meshheading:2941372-Metabolic Clearance Rate, pubmed-meshheading:2941372-Natriuresis, pubmed-meshheading:2941372-Phosphates, pubmed-meshheading:2941372-Potassium, pubmed-meshheading:2941372-Renin, pubmed-meshheading:2941372-Sodium, pubmed-meshheading:2941372-p-Aminohippuric Acid
pubmed:year
1986
pubmed:articleTitle
Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't