Linked Life Data

2940951

Source:http://linkedlifedata.com/resource/pubmed/id/2940951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-7-9
pubmed:abstractText
Mast cells derived from mouse bone marrow fail to demonstrate a disodium-cromoglycate-induced inhibition of mediator release when the cromolyn is added simultaneously with a secretagogue. To investigate the long-term effects of cromolyn exposure, cells from BALB/C femoral bone marrow stimulated with IL-3 were cultured in the presence of 1 to 100 microM cromolyn and demonstrated a similar viability and ability to proliferate as cells cultured in medium alone. Those cultured in cromolyn exhibited a significantly decreased A23187- or antigen-induced release of beta-hexosaminidase (4.3 +/- 0.7% versus 9.2 +/- 1.0%, p less than 0.01) compared with control cells. The adenosine-induced potentiation of mediator release was diminished to a comparable degree after cromolyn exposure in culture. This inhibition was dose-dependent between 1 and 100 microM cromolyn, evident by 5 days, reversible in 6 more days, and applied to immunoreactive leukotriene C4 generation as well. Bone marrow mast cells respond to chronic cromolyn exposure with a global inhibition of mediator release, but the basis for this response is unknown.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1105-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Cromolyn inhibition of mediator release in mast cells derived from mouse bone marrow.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't