Linked Life Data

2940523

Source:http://linkedlifedata.com/resource/pubmed/id/2940523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-7-10
pubmed:abstractText
Organ culture of the rat ventral prostate has been evaluated as a model for studying the biological effects of androgen agonists, androgen antagonists, and estrogens. Explants were cultured for up to 8 days, and incorporation of (3H)-thymidine and (3H)-uridine by the explants was measured. Dihydrotestosterone (DHT) increased the incorporation of (3H)-thymidine/microgram DNA when compared with the untreated controls at 4 days, P less than .05; and at 6 days, P less than .01. Enhanced uptake in explants from 6 to 8-week old rats also was observed with 10 nM estradiol (P less than .05) and 10 nM cyproterone acetate (P less than .02). DHT (10 nM) caused greater enhancement of uptake in explants from 3-week-old rats than in explants from 6- or 12-week-old rats. In contrast, estradiol (E2) increased incorporation only in prostates from the 6-week-old rats. Since both DHT and E2 can enhance (3H)-thymidine uptake even though they are associated with strikingly different effects on prostate morphology, it suggests that their effects on (3H)-thymidine incorporation are mediated by different cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-4137
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-62
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Age dependency of androgen and estrogen effects on incorporation of (3H)-thymidine by rat prostates in organ culture.
pubmed:publicationType
Journal Article