Linked Life Data

2940202

Source:http://linkedlifedata.com/resource/pubmed/id/2940202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-7-9
pubmed:abstractText
The authors have studied the antiproliferative and anticontractile effects of fluorouracil, fluorouridine, and fluorodeoxyuridine on rabbit dermal fibroblasts. All three drugs have antiproliferative effects, the order of their efficacy being fluorodeoxyuridine greater than fluorouridine greater than fluorouracil. In contrast, only fluorouridine and fluorouracil have anticontractile effects. Fluorouridine requires less time of exposure and has greater anticontractile effects than fluorouracil. Thymidine eliminates the antiproliferative effects of fluorodeoxyuridine, but has no effect on either the antiproliferative or anticontractile effects of fluorouracil and fluorouridine. These results suggest that the anticontractile effects of the fluoropyrimidines are caused by their incorporation into RNA and not by the inhibition of DNA synthesis. Metabolites of fluorouracil may provide enhanced control of cell proliferation and contractility in the management of ocular disorders such as proliferative vitreoretinopathy and glaucoma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
940-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Fluoropyrimidine treatment of ocular cicatricial disease.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.