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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-5-23
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pubmed:abstractText |
The in vitro effect of Cyclosporin A on the regulation of immunoglobulin production was investigated in 16 patients with primary biliary cirrhosis. A significant improvement in concanavalin A induced suppression of IgG and IgM producing cells was observed after prior incubation of mononuclear cells with 300 ng/ml Cyclosporin A for 30 minutes. No effect was seen on spontaneous or pokeweed mitogen induced immunoglobulin production, nor on con A induced suppression if Cyclosporin A was added after 24 hours. Incubation of mononuclear cells with a variable dose of Cyclosporin A showed an effect only at 250-500 ng/ml. Higher and lower doses had no effect. This dose dependent effect of Cyclosporin A is likely to be related to a differential inhibitory effect on T helper and T suppressor cells and may underlie the clinical benefit being observed in current clinical trials.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-14353274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-148989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-155909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-2933448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-328380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-4175170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-5947845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6108396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6135075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6136647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6143202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6144889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6159410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6193229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6197443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6222651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6223763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6367043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6406595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6445383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6453900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6456149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6783967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6840802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6966298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-6967438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-7022839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2939007-91781
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2939007-Aged,
pubmed-meshheading:2939007-Cells, Cultured,
pubmed-meshheading:2939007-Concanavalin A,
pubmed-meshheading:2939007-Cyclosporins,
pubmed-meshheading:2939007-Female,
pubmed-meshheading:2939007-Humans,
pubmed-meshheading:2939007-Immunoglobulin G,
pubmed-meshheading:2939007-Immunoglobulin M,
pubmed-meshheading:2939007-Liver Cirrhosis, Biliary,
pubmed-meshheading:2939007-Male,
pubmed-meshheading:2939007-Middle Aged,
pubmed-meshheading:2939007-T-Lymphocytes, Regulatory
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pubmed:year |
1986
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pubmed:articleTitle |
In vitro effect of cyclosporin A on immunoglobulin production and concanavalin A induced suppression in primary biliary cirrhosis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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