Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1986-5-22
|
| pubmed:abstractText |
We used total lymphoid irradiation (TLI; total dose = 3400 rad) to treat the lupus-like renal disease of 6-mo-old female NZB/NZW mice. Similar to our past studies, this treatment resulted in a marked prolongation of survival, decrease in proteinuria, and decrease in serum anti-DNA antibodies compared with untreated littermate controls. Although there was no evidence of disease recurrence in TLI-treated mice until after 12 mo of age, the in vitro proliferative response to phytohemagglutinin by NZB/NZW spleen cells recovered within 6 wk such that responses were greater than control NZB/NZW animals. A similar recovery and overshoot after TLI were evident in the primary antibody response to the T cell-dependent antigen sheep red blood cells (SRBC). Both the total and IgG anti-SRBC antibody responses after TLI were greater than those of untreated NZB/NZW controls, and were comparable with those of untreated non-autoimmune mice. Despite this increased response to mitogens and antigens after TLI, we noted a decrease in spontaneous splenic IgG-secreting cells and a decrease in IgG but not IgM antinuclear antibody production. Nonspecific suppressor cells of the mixed leukocyte response were detectable in the spleens of NZB/NZW mice early after TLI. However, the disappearance of suppressor cells was not associated with recrudescence of disease activity. Furthermore, transfer of large numbers of spleen cells from TLI-treated NZB/NZW mice did not result in disease suppression in untreated age-matched recipients. In summary, treatment of NZB/NZW mice with TLI results in a prolonged remission in autoimmune disease, which is achieved in the absence of generalized immunosuppression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
136
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3259-65
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2937842-Animals,
pubmed-meshheading:2937842-Antibody-Producing Cells,
pubmed-meshheading:2937842-Autoimmune Diseases,
pubmed-meshheading:2937842-B-Lymphocytes,
pubmed-meshheading:2937842-Female,
pubmed-meshheading:2937842-Immunoglobulin Allotypes,
pubmed-meshheading:2937842-Immunosuppression,
pubmed-meshheading:2937842-Leukocyte Count,
pubmed-meshheading:2937842-Lipopolysaccharides,
pubmed-meshheading:2937842-Lymphocyte Activation,
pubmed-meshheading:2937842-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:2937842-Mice,
pubmed-meshheading:2937842-Mice, Inbred BALB C,
pubmed-meshheading:2937842-Mice, Inbred NZB,
pubmed-meshheading:2937842-Phytohemagglutinins,
pubmed-meshheading:2937842-Spleen,
pubmed-meshheading:2937842-T-Lymphocytes,
pubmed-meshheading:2937842-Time Factors,
pubmed-meshheading:2937842-Whole-Body Irradiation
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Treatment of NZB/NZW mice with total lymphoid irradiation: long-lasting suppression of disease without generalized immune suppression.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|