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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-5-1
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pubmed:abstractText |
We have attempted to characterize the 5-hydroxytryptamine (5-HT) receptors mediating bronchoconstriction, vasodilatation, vasodepression and tachycardia in anaesthetized cats following bilateral vagosympathectomy and beta-adrenoceptor blockade with propranolol. 5-HT (1-100 micrograms/kg-1 i.v.) caused dose-related bronchoconstriction and tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance. In contrast, 5-carboxamidotryptamine (5-CT; 0.01-1 micrograms kg-1 i.v.) caused consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate. 5-CT did not cause bronchoconstriction. The 5-HT-induced bronchoconstriction was dose-dependently antagonized by methiothepin, methysergide and ketanserin (10-100 micrograms kg-1 i.v.). The highest doses used of these antagonists did not antagonize bronchoconstriction induced by prostaglandin F2 alpha. The high potency of all three antagonists indicate a 5-HT2-receptor mediated effect. The 5-HT- and 5-CT-induced tachycardia as well as the 5-CT-induced vasodepressor and carotid arterial vasodilator responses were dose-dependently antagonized by low doses of methiothepin (10-100 micrograms kg-1 i.v.) and by high doses of methysergide (100-1000 micrograms kg-1 i.v.) but were little affected by ketanserin in doses up to 1000 micrograms kg-1 i.v. These selective effects of 5-CT appear to be mediated by '5-HT1-like' receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-13070267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-13777992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-14941052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-16992663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-4568412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-530254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6126575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-618595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6205240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6261070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-634380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6396525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6472484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6615080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6646239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-6662198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-7334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2937503-7463047
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2937503-Animals,
pubmed-meshheading:2937503-Blood Pressure,
pubmed-meshheading:2937503-Cats,
pubmed-meshheading:2937503-Female,
pubmed-meshheading:2937503-Heart Rate,
pubmed-meshheading:2937503-Ketanserin,
pubmed-meshheading:2937503-Male,
pubmed-meshheading:2937503-Methiothepin,
pubmed-meshheading:2937503-Methysergide,
pubmed-meshheading:2937503-Piperidines,
pubmed-meshheading:2937503-Receptors, Serotonin,
pubmed-meshheading:2937503-Serotonin,
pubmed-meshheading:2937503-Serotonin Antagonists,
pubmed-meshheading:2937503-Vascular Resistance,
pubmed-meshheading:2937503-Vasodilation
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pubmed:year |
1986
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pubmed:articleTitle |
5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats.
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pubmed:publicationType |
Journal Article
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