| pubmed-article:2937311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2937311 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:2937311 | lifeskim:mentions | umls-concept:C0027481 | lld:lifeskim |
| pubmed-article:2937311 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:2937311 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2937311 | lifeskim:mentions | umls-concept:C1149098 | lld:lifeskim |
| pubmed-article:2937311 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:2937311 | pubmed:dateCreated | 1986-4-18 | lld:pubmed |
| pubmed-article:2937311 | pubmed:abstractText | Although synthetic atrial natriuretic peptides (ANP) have potent natriuretic/diuretic properties, the renal mechanisms underlying these effects are not yet clearly defined. To determine the possible sites of action for ANP within the kidney, we have localized 125I-ANP binding sites by in vitro autoradiography. Slices of rat kidney were incubated with 150 pM 125I-ANP [alpha-rat ANP (alpha-rANP), 28 amino acids] alone or in the presence of 10 nM or 1 microM unlabeled ANP. Autoradiography was performed using LKB Ultrofilm or emulsion-coated cover slips together with histochemical/immunohistochemical staining of specific tubular segments. High-affinity 125I-ANP binding sites were concentrated over glomeruli and to a lesser extent over the arterial vasculature. Lower-affinity binding sites were seen over proximal tubules and inner medullary collecting ducts. The remainder of the nephron was unlabeled. The localization of high-affinity 125I-ANP binding sites in rat kidney is consistent with a glomerular filtration/hemodynamic mechanism as the principal means by which ANP promotes natriuresis/diuresis. | lld:pubmed |
| pubmed-article:2937311 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2937311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2937311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2937311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2937311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2937311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2937311 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2937311 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2937311 | pubmed:author | pubmed-author:FanestilD DDD | lld:pubmed |
| pubmed-article:2937311 | pubmed:author | pubmed-author:HealyD PDP | lld:pubmed |
| pubmed-article:2937311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2937311 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:2937311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2937311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2937311 | pubmed:pagination | F573-8 | lld:pubmed |
| pubmed-article:2937311 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:meshHeading | pubmed-meshheading:2937311-... | lld:pubmed |
| pubmed-article:2937311 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2937311 | pubmed:articleTitle | Localization of atrial natriuretic peptide binding sites within the rat kidney. | lld:pubmed |
| pubmed-article:2937311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2937311 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2937311 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2937311 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2937311 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2937311 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2937311 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2937311 | lld:pubmed |
