| pubmed-article:293685 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0079382 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:293685 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:293685 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:293685 | pubmed:dateCreated | 1980-3-17 | lld:pubmed |
| pubmed-article:293685 | pubmed:abstractText | We have recently demonstrated that normal hemopoietic cells express RNA sequences that are homologous to sequences specific for the Friend erythroleukemia virus genome [Bernstein, A., Gamble, C., Penrose, D. & Mak, T. W. (1979) Proc. Natl. Acad. Sci. USA 76, 4455-4459]. In this communication, we report that the Fv-2 locus, the major genetic determinant controlling host susceptibility to erythroleukemia induction by Friend leukemia virus, also controls the expression of endogenous sequences related to the replication-defective component of Friend leukemia virus, Friend spleen focus-forming virus (SFFV), in normal uninfected mice. Two independent congeneic pairs of mice [C57BL/6 (B6) and B6.S; B6 and B6.C(H-7(b))], differing only in a small region of the mouse genome including the Fv-2 locus, were used for this purpose. In both cases, molecular hybridization analysis indicated that the presence of SFFV-related RNA sequences in normal mice was associated with the Fv-2(s) allele: bone marrow or spleen cellular RNA from Fv-2(rr) B6 mice contained no detectable SFFV-related sequences, whereas their congeneic Fv-2(ss) pairs contained relatively high levels of these RNA sequences. The absence of these RNA sequences in Fv-2(rr) mice was not due to deletion of these sequences from the DNA of Fv-2(rr) mice. Repopulation of lethally irradiated Fv-2(rr) mice with syngeneic Fv-2(rr) bone marrow cells did not lead to any increase in the levels of these SFFV-related RNA sequences, suggesting that the expression of these sequences is still reduced or inhibited in actively cycling Fv-2(rr) hemopoietic cells. Infection with Friend leukemia virus resulted in the appearance of high levels of RNA homologous to SFFV-specific sequences in the leukemic spleens of B6.S (Fv-2(ss)) mice, whereas these cellular RNA sequences could not be detected in the spleens of Friend virus-infected B6 (Fv-2(rr)) mice. The demonstration that the same gene locus controls both the expression of exogenous SFFV-specific sequences and erythroleukemia induction by Friend leukemia virus suggests that these sequences may be necessary for erythroleukemic transformation. In addition, the finding that the Fv-2 gene locus controls the expression of endogenous SFFV-related sequences suggests that these sequences may also be involved in normal hemopoiesis. | lld:pubmed |
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| pubmed-article:293685 | pubmed:language | eng | lld:pubmed |
| pubmed-article:293685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:293685 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:293685 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:293685 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:293685 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:293685 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:293685 | pubmed:author | pubmed-author:BernsteinAA | lld:pubmed |
| pubmed-article:293685 | pubmed:author | pubmed-author:AxelradA AAA | lld:pubmed |
| pubmed-article:293685 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:293685 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:293685 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:293685 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:293685 | pubmed:pagination | 5809-12 | lld:pubmed |
| pubmed-article:293685 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:293685 | pubmed:meshHeading | pubmed-meshheading:293685-D... | lld:pubmed |
| pubmed-article:293685 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:293685 | pubmed:articleTitle | Fv-2 locus controls expression of Friend spleen focus-forming virus-specific sequences in normal and infected mice. | lld:pubmed |
| pubmed-article:293685 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:19882 | entrezgene:pubmed | pubmed-article:293685 | lld:entrezgene |
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