|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1980-3-17
|
|
pubmed:abstractText |
The Rfv-3 gene was found to influence the level of Friend leukemia virus production in spleens of leukemic mice later than 30 days after virus inoculation. Rfv-3r/s mice [(B10.A X A)F1 and (B10.A X A.BY)F1] had decreased spleen virus levels 30-90 days after virus inoculation compared to Rfv-3s/s mice [A.BY, A, BALB.B, and (BALB/c X A)F1)]. In (B10.A X A)F1 X A backcross mice the spleen virus titer segregated with the level of viremia. The Rfv-3 gene appeared to act by controlling anti-Friend virus antibody production. The interaction of antiviral antibody with infected cells led to a decrease in release of infectious virus by late leukemic spleen cells in Rfv-3r/s mice to 1/300th that in Rfv-3s/s mice. This decrease in virus release appeared to be due to interference with the virus budding process due to antibody-mediated modulation of virus-induced cell surface antigens.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-1081583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-1176889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-1244422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-13416470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-13618884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-176781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-185295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-186438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-186612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-190766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-195339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-200199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-202080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-281446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-281570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-284359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-286744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-327016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4123810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4430891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4569167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4606230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4610077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4742777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4855737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-4925356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5037434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5167068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5233851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5334769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5636554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5636556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-5923328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-634370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-634371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-641338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/293683-67223
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5784-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:293683-Animals,
pubmed-meshheading:293683-Antibodies, Viral,
pubmed-meshheading:293683-Antigen-Antibody Reactions,
pubmed-meshheading:293683-Antigens, Surface,
pubmed-meshheading:293683-Antigens, Viral,
pubmed-meshheading:293683-Blood,
pubmed-meshheading:293683-Friend murine leukemia virus,
pubmed-meshheading:293683-Genes, Viral,
pubmed-meshheading:293683-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:293683-Leukemia, Experimental,
pubmed-meshheading:293683-Spleen,
pubmed-meshheading:293683-Virus Replication
|
|
pubmed:year |
1979
|
|
pubmed:articleTitle |
Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.
|
|
pubmed:publicationType |
Journal Article
|
