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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-4-3
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pubmed:abstractText |
We measured the inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig hippocampal membranes by 5-HT, 5-carboxamidotryptamine (CAT) and 8-hydroxy-2-(di-n-propylamino) tetralin (PAT). Low concentrations of these agonists inhibited forskolin-stimulated adenylate cyclase activity in a concentration-dependent and saturable manner. The antagonist spiperone shifted the concentration-response curve to CAT to the right in a parallel manner. The EC50 values of CAT, PAT and 5-HT and the KB of spiperone suggest that this receptor may correspond to the 5-HT1A binding site.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
231-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2936612-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:2936612-Adenylate Cyclase,
pubmed-meshheading:2936612-Animals,
pubmed-meshheading:2936612-Dose-Response Relationship, Drug,
pubmed-meshheading:2936612-Forskolin,
pubmed-meshheading:2936612-Guinea Pigs,
pubmed-meshheading:2936612-Hippocampus,
pubmed-meshheading:2936612-Male,
pubmed-meshheading:2936612-Receptors, Serotonin,
pubmed-meshheading:2936612-Serotonin,
pubmed-meshheading:2936612-Serotonin Antagonists,
pubmed-meshheading:2936612-Spiperone,
pubmed-meshheading:2936612-Tetrahydronaphthalenes
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pubmed:year |
1985
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pubmed:articleTitle |
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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