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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-2-26
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pubmed:abstractText |
Suppressor T-cell function was analyzed in seven children with acquired autoimmunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Four of the patients had markedly increased serum IgG levels. All patients had elevated percentages and absolute numbers of peripheral blood T8 cells. In vitro concanavalin A generation of suppressor cells for T-cell mitogenic responses and suppression of pokeweed mitogen-driven immunoglobulin secretion were diminished in all patients. After intravenous treatment with gamma globulin, four patients regained in vitro suppression of pokeweed mitogen-driven gamma globulin secretion. Treatment with intravenous gamma globulin also modified in vitro suppressor T-cell functions in children with AIDS or ARC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-922X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2936236-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2936236-Child,
pubmed-meshheading:2936236-Child, Preschool,
pubmed-meshheading:2936236-Concanavalin A,
pubmed-meshheading:2936236-Humans,
pubmed-meshheading:2936236-Immunoglobulin G,
pubmed-meshheading:2936236-Infant,
pubmed-meshheading:2936236-Injections, Intravenous,
pubmed-meshheading:2936236-Interleukin-2,
pubmed-meshheading:2936236-L-Lactate Dehydrogenase,
pubmed-meshheading:2936236-Suppressor Factors, Immunologic,
pubmed-meshheading:2936236-T-Lymphocytes, Regulatory
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pubmed:year |
1986
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pubmed:articleTitle |
Restoration of suppressor T-cell functions in children with AIDS following intravenous gamma globulin treatment.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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