Linked Life Data

2935451

Source:http://linkedlifedata.com/resource/pubmed/id/2935451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-3-12
pubmed:abstractText
The effects of 17 beta-estradiol and progesterone on the uptake of adenosine by rat cerebral cortical synaptosomes have been correlated with the ability of these gonadal steroids to potentiate the depressant actions of adenosine on the spontaneous firing of rat cerebral cortical neurons. 17 beta-estradiol hemisuccinate competitively inhibited adenosine uptake with a Ki of 0.5 microM (Lineweaver-Burk plot) or 0.78 microM (Dixon plot). The Ki for progesterone was 0.34 microM (Lineweaver-Burk plot) or 0.36 microM (Dixon plot). When applied by iontophoresis, both steroids potentiated the depressant effects of adenosine on the firing of rat cerebral cortical neurons. Potentiation of the effect of endogenously released adenosine would account for the central depressant actions of these steroids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.