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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-3-5
|
| pubmed:abstractText |
Rats pretreated with the monoamine oxidase inhibitor, phenelzine 18 h (46.8 mg/kg) and 90 min (11.7 mg/kg) previously or only 90 min (46.8 mg/kg) previously developed a 5-HT dependent syndrome (including wet-dog shakes, WDS) when given the 5-HT uptake inhibitor, paroxetine (11.6 mg/kg). After 2 h, but only in rats pretreated with 2 injections of phenelzine, there was a gradual reduction in the number of cortical 5-HT2 receptors, determined in vitro with [3H]ketanserin, and this was temporally related to a reduction in the frequency of WDS. Both effects (down-regulation and WDS) were prevented by the 5-HT2 receptor antagonist, pirenperone. A second injection of paroxetine at 3 h evoked additional WDS in rats pretreated with 1 injection of phenelzine but not in rats pretreated with 2 injections, suggesting that spinal 5-HT2 receptors might also have been down-regulated at the same time. Similar results were obtained when rats were pretreated instead with the selective MAO A inhibitor, clorgyline or when given either citalopram or fenfluramine instead of paroxetine. 5-HTP also evoked WDS in phenelzine-treated rats and markedly increased brain 5-HT concentration but only slowly down-regulated 5-HT2 receptors; in carbidopa-treated animals, 5-HTP was without effect on receptor numbers despite production of frequent WDS. It thus appears that drugs which increase synaptic 5-HT (as indicated by production of WDS) by interference with the release or reuptake of 5-HT more readily down-regulate 5-HT2 receptors than 5-HTP which does not directly affect these mechanisms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-Hydroxytryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Carbidopa,
http://linkedlifedata.com/resource/pubmed/chemical/Citalopram,
http://linkedlifedata.com/resource/pubmed/chemical/Fenfluramine,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxydimethyltryptamines,
http://linkedlifedata.com/resource/pubmed/chemical/Paroxetine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenelzine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Propylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-81
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2935412-5-Hydroxytryptophan,
pubmed-meshheading:2935412-Animals,
pubmed-meshheading:2935412-Antidepressive Agents,
pubmed-meshheading:2935412-Carbidopa,
pubmed-meshheading:2935412-Cerebral Cortex,
pubmed-meshheading:2935412-Citalopram,
pubmed-meshheading:2935412-Drug Interactions,
pubmed-meshheading:2935412-Fenfluramine,
pubmed-meshheading:2935412-Male,
pubmed-meshheading:2935412-Methoxydimethyltryptamines,
pubmed-meshheading:2935412-Paroxetine,
pubmed-meshheading:2935412-Phenelzine,
pubmed-meshheading:2935412-Piperidines,
pubmed-meshheading:2935412-Propylamines,
pubmed-meshheading:2935412-Rats,
pubmed-meshheading:2935412-Rats, Inbred Strains,
pubmed-meshheading:2935412-Receptors, Serotonin,
pubmed-meshheading:2935412-Reflex,
pubmed-meshheading:2935412-Serotonin,
pubmed-meshheading:2935412-Time Factors
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Effects of antidepressant drug combinations on cortical 5-HT2 receptors and wet-dog shakes in rats.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|